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Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders ofsex development

Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 498-505 doi: 10.1007/s11684-020-0791-8

Abstract: Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologiesDistinguishing the various causes of DSD is quite difficult in clinical practice, even for senior generalfor DSD.was jointly constructed by experts on DSD and engineers of artificial intelligence.and three causes other than DSD as the differential diagnosis.

Keywords： disorders of sex development (DSD)     intelligent diagnosis     dynamic uncertain causality graph    

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Progress in studies of sex determination mechanisms and sex control techniques in

Qian ZHOU,Songlin CHEN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 113-123 doi: 10.15302/J-FASE-2016093

Abstract: It has a female heterogametic sex determination system (ZW/ZZ) and environmental factors can induce sex-reversalThis paper reviews the progress in research on sex determination mechanisms research in our laboratoryand for differentiation of the fish sex.Development and improvement of sex control technologies, including artificial gynogenesis and productionsex management in artificial culturing of .

Keywords： Cynoglossus semilaevis     sex determination     sex control technique    

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Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 242-249 doi: 10.15302/J-FASE-2014018

Abstract: This dermal hyperpigmentation phenotype is controlled by the sex-linked inhibitor of dermal melanin gene

Keywords： sex-linked inhibitor of dermal melanin (Id)     Silkie     chromosome Z    

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Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 290-300 doi: 10.1007/s11684-013-0277-z

Abstract: With appropriate safeguards, thalidomide may benefit patients suffering from a broad variety of disorders

Keywords： thalidomide     multiple myeloma     lymphoma    

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Isolation and characterization of a bacterial strain that efficiently degrades sex steroid hormones

JI Shulan, LIU Zhipeng, REN Haiyan, LIU Zhipei

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 325-328 doi: 10.1007/s11783-007-0055-8

Abstract: A bacterial strain, ZY3, growing on sex steroid hormones as the sole source of carbon and energy wasThe degradation rate of the sex steroid hormones increased to 87% and 85% after the addition of maltose

Keywords： maltose     optimum temperature     prophylactic     3-methoxy-17-hydroxy-1     3     5     addition    

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Frontiers of Medicine doi: 10.1007/s11684-023-1006-x

Abstract: Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge

Keywords： neurodevelopmental disorder     autosomal recessive intellectual disability     consanguinity     spastic paraplegia     hearing loss     TMEM141    

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract: chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 471-481 doi: 10.1007/s11684-019-0686-8

Abstract: the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disordersmicrobial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disordersmicrobiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders

Keywords： antibiotics     tacrolimus     glucose disorders     microbiome    

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Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 316-319 doi: 10.1007/s11684-007-0061-z

Abstract: influencing factors, as well as to discuss the relationship between the occurrence of glucose metabolism disordersPatients with abnormal HbAc are more likely to have a higher risk of having glucose metabolism disorders

Keywords： significant difference     occurrence     hemoglobin     risperidone treatment     abnormal    

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A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders Review

Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang

Engineering 2020, Volume 6, Issue 4,   Pages 462-467 doi: 10.1016/j.eng.2019.06.008

Abstract: research projects have recently been carried out to study the etiology and mechanisms of psychiatric disordersAlthough psychiatric disorders are part of the brain sciences, psychiatrists still diagnose them basedunderstanding of the etiology and pathogenesis of major psychiatric diseases, which can help in the developmentreason, this study briefly reviews three main brain observation techniques used to study psychiatric disorders

Keywords： Artificial intelligence     Psychiatric disorders     Neuroimaging    

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects Review

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Engineering 2023, Volume 30, Issue 11,   Pages 170-189 doi: 10.1016/j.eng.2023.05.009

Abstract:

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly delivermolecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) for treating various skin disorderssummarized the various applications, emerging challenges, and developmental prospects of MNs in skin disorders

Keywords： Microneedles     Transdermal drug delivery system     Skin disorders     Treatments     Challenges     Prospects    

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Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Engineering 2020, Volume 6, Issue 4,   Pages 415-423 doi: 10.1016/j.eng.2019.07.026

Abstract: crosstalk between the gut microbiota and the brain via the gut–brain axis, and on the onset and developmentof neurological disorders triggered by gut microbiota dysbiosis.neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders, but also may lead to the development of potential diagnosis biomarkers and intervention strategiestargeting microbiota dysbiosis for neurological disorders.

Keywords： Gut microbiota     Gut–brain axis     Neurological disorders     Intervention strategies    

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Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders Review

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Engineering 2023, Volume 29, Issue 10,   Pages 73-82 doi: 10.1016/j.eng.2023.03.004

Abstract:

Disturbed cholesterol and glucose homeostasis play crucial roles in the development of various diseasesThis vicious cycle promotes the occurrence and development of the aforementioned diseases.

Keywords： Chinese herbal medicines     Hyperlipidemia     Hyperglycemia     Cardiovascular and cerebrovascular diseases    

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Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 90-99 doi: 10.15302/J-FASE-2015045

Abstract: Myostatin gene ( ) knockout (KO) mice show possible effects for the prevention or treatment of metabolic disorders

Keywords： myostatin     transforming growth factor-β family     skeletal muscle     metabolic disorders     chromatography     mass    

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Title Author Date Type Operation

Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders ofsex development

Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang

Journal Article

Progress in studies of sex determination mechanisms and sex control techniques in

Qian ZHOU,Songlin CHEN

Journal Article

Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

Journal Article

Therapeutic effects of thalidomide in hematologic disorders: a review

Miao Xu, Yu Hou, Lei Sheng, Jun Peng

Journal Article

Isolation and characterization of a bacterial strain that efficiently degrades sex steroid hormones

JI Shulan, LIU Zhipeng, REN Haiyan, LIU Zhipei

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Journal Article

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

Journal Article

A Brief Review of Artificial Intelligence Applications and Algorithms for Psychiatric Disorders

Guang-Di Liu, Yu-Chen Li, Wei Zhang, Le Zhang

Journal Article

Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Tingting Peng, Yangyan Chen, Wanshan Hu, Yao Huang, Minmin Zhang, Chao Lu, Xin Pan, Chuanbin Wu

Journal Article

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Journal Article

Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Journal Article

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Journal Article